Scientist (m/f/d) – Antibody and Protein Biochemistry

About the company

Tacalyx is a biopharmaceutical company developing innovative therapeutics to target tumor-associated carbohydrate antigens (TACAs). To strengthen our team in Berlin-Adlershof, we are seeking an experienced, enthusiastic, and self-motivated Scientist – Antibody and Protein Biochemistry. This laboratory-based role focuses on the design, expression, purification, characterization and modification of antibodies and recombinant proteins to support therapeutic development. It also includes the coordination and scientific oversight of external research activities.

Your tasks

• Design of protein and antibody constructs, including chimeric, humanized and multispecific mAbs
• Chemical and enzymatic modification of antibodies (e.g. fragmentation, labeling and conjugation)
• Characterization of antibody affinity, integrity, activity and stability using methods such as SPR, ELISA, Western blotting and thermal shift assays
• Molecular cloning and expression of recombinant proteins in prokaryotic and mammalian cells
• Development and implementation of protein purification workflows using an ÄKTA chromatography system
• Documentation and reporting of results and evaluation of relevant scientific literature
• Collaboration in project teams advancing antibodies toward first-in-human studies
• Coordination and scientific oversight of projects with external partners (e.g. CROs, academic groups)

Requirements

_Essential qualifications:_

• PhD in biological sciences or a related discipline, with substantial hands-on laboratory experience
• Strong expertise in antibody and protein biochemistry, including cloning, expression, purification and analytical characterization
• Practical experience with protein chromatography and biochemical assays
• Strong communication skills in English

_Preferred qualifications:_

• Relevant postdoctoral or industry experience
• Proficiency in protein and antibody construct design
• Skills in HPLC-based method development
• Practical expertise in SPR-based measurements of binding kinetics and affinity
• Familiarity with antibody humanization
• Knowledge of carbohydrate biology

What we offer

• A permanent, full-time position with a competitive salary and excellent opportunities for professional and personal development
• A diverse, international workforce with a dynamic working environment that fosters creativity, innovation and teamwork
• The opportunity to contribute to antibody programs advancing toward first-in-human studies
• A performance-based annual bonus
• Regular company and team events
• A fully employer-funded public transport pass (“Job Ticket”)

How to apply

To apply, please send your CV and cover letter in English or German to info@tacalyx.com, stating your earliest possible start date and salary expectations.

Other

Applicants must have valid work permit for Germany by their employment start date.