Research Associate II/III– Bioanalytical/In Vitro ADME/DMPK

Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

Nurix Therapeutics is searching for a motivated Research Associate to join our Bioanalytical-In Vitro DMPK team. The successful candidate will contribute to the bioanalytical efforts to support Nurix drug discovery programs involving in vivo and in vitro studies. We are seeking a highly motivated research associate to characterize the in vitro and in vivo ADME properties of drug candidates. The primary responsibilities will be to conduct bioanalysis for in vivo samples and to conduct in vitro experiments. The scope of the daily responsibilities for this position includes, but is not limited to, developing bioanalytical methods, quantitating drug candidates and their metabolites, endogenous biomarkers in biological matrices (e.g. blood, plasma, tissue, tumor, CSF, etc.), reporting bioanalytical results and managing projects outsourced in CROs to support all in vitro and in vivo studies. The successful candidate will have extensive experience in bioanalytical method development and sample analysis using LC-MS/MS and other analytical techniques.

Key Responsibilities

Provide bioanalytical support for in-house PK, non-GLP safety TK

Conduct bioanalytical method development and qualification to support drug, metabolite and biomarker analysis

Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples

Conduct in-vitro stability assays to understand metabolism of drugs

Perform metabolic identification (MetID) using LC-QTOF MS/MS, including accurate mass analysis, fragment interpretation and biotransformation pathway assignment

Independently operate, troubleshoot and maintain LC-MS/MS systems

Participate in multidisciplinary project teams and collaborate with other departments to understand bioanalytical needs for both PK and PD support

Manage projects conducted at CROs to ensure high quality bioanalytical data is delivered to meet project timelines

Maintain accurate and detailed scientific electronic laboratory notebooks

Perform all duties in keeping with the Company’s core values, policies and all applicable regulations

Preferred Qualifications & Experience

Experience with H/UPLC and mass spectrometry

Good working knowledge of SCIEX LC-MS/MS systems for small molecule quantitation

PK analysis using Phoenix or other data management software

Management experience with CROs for outsourcing BA activities is preferred

Provide sample analysis to support PK, PK/PD, PK/efficacy, distribution, metabolism, and non-GLP toxicology studies

Identify issues and troubleshoot scientific equipment including LC-MS/MS, select and develop appropriate methods to perform experiments, analyze data and prepare related reports.

Excellent oral and written communication skills

Minimum Requirements

BS or master’s with >4 years’ experience working in a discovery setting using LC-MS/MS within a pharmaceutical/biotechnology company

Broad experience in small molecule drug candidate bioanalytical assay development/sample analysis in different biological matrices using LC-MS/MS

Experience with AB SCIEX mass spectrometry software

Excellent written, verbal communications and interpersonal skills to collaborate with internal and external partners in a matrix environment

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative

Solutions and results-oriented focus

Hands-on approach; resourceful and open to diverse points of view

Location: Brisbane, CA - Onsite

Salary Ranges:

RA II $92,891 - $106,507

RA III $110,101 - $124,079

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

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