Sr Staff Mechanical Engineer

Senior Staff Mechanical Engineer (Onsite in Wilsonville, OR)

Summary

We are seeking a Senior Staff Mechanical Engineer to design, build, and test our next-generation automated wet-lab instruments. Based primarily on-site in Wilsonville, OR with partial remote flexibility, this role requires occasional travel to Twist in South San Francisco, CA and to vendor locations.

Responsibilities:

Use SolidWorks to design multiple instruments that integrate liquid handling, consumable handling, imaging & robotics that meet or exceed System & Hardware requirements

Manage and use SolidWorks AI Agents to create new hardware designs leveraging parts & assemblies already in Twist’s PDM environment

Specify all hardware (off-the-shelf and custom) for the instruments

Work with other team members to develop and refine requirements

Perform tolerance analysis as needed

Support contract manufacturers and vendors as the Mechanical Technical Lead for your designs

Work with other team members to execute and support Factory and Site Acceptance Testing

Compile content and hold multiple design reviews as needed

Use SolidWorks to design & build test fixtures as needed to de-risk concept features or test sub-systems

Support Process Systems Engineers as needed during Concept Development and all other project phases

Provide system fluidics and electrical design documentation

Build, debug, calibrate, and verify the instruments with help from technicians and Process System Engineers

Create full models, part files, part drawings, assembly drawings & a BOM for the System

Maintain full design control and release via 3D- Experience (Dassault Systèmes)

Order & track parts for system builds

Provide updated designs for obsolete parts

Lead hardware design for next-generation custom instrumentation, from concept and feasibility through post-production support.

Provide concept architectures for Roadmap development

Required Skills:

12+ years of experience as a Senior Mechanical Engineer(or higher) and a 4-year degree in mechanical engineering, or 8 years of experience as a Senior Mechanical Engineer (or higher), with a graduate degree in mechanical engineering

Expert in SolidWorks, with a proven record of delivering end-to-end design packages, complete engineering documentation, and fabrication-ready deliverables.

Lead Mechanical Engineer of at least 2 benchtop or larger instruments that went into Production

Strong experience with robotics/mechatronics and specifying electronic devices

Extensive experience designing hardware for fluidics systems, including custom manifolds and integration of pumps, valves, sensors, regulators, etc.

Proven track record of collaborating with cross-functional teams—including engineers, scientists, and project managers—across the entire project lifecycle, from initial concept to post-release monitoring

Experience managing a CAD PDM system

Excellent communication and writing skills, and the ability to work in a fast-paced team environment

Very strong documentation skills

Comfortable working with evolving requirements and a dynamic work environment driving hardware designs for multiple projects

Proven ability to perform System Integration

Proven ability to perform Systems Testing, including Factory/Site Acceptance Testing

Additional Bonus Skills:

Proficiency in 3DExperience

Experience with mechanical design for optical systems

In-depth knowledge and use of machine shop tools (band saws, Mill, drill press, sanders)

Experience performing electrical and electronics troubleshooting

Experience with Altium, Lucid, or other software tools that can be used to create wiring or plumbing diagrams

Experience in specifying device control

Experience compiling and releasing QA documentation

Experience as an Instrument Technical Lead or Instrumentation Systems Engineer

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.