Research Assistant in RNA dynamics with a focus on microRNA

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The Department of Medical Biochemistry and Microbiology (IMBIM) at Uppsala University constitutes a broad international environment for research and teaching. At IMBIM, basic research is conducted in biochemistry, cell and molecular biology, tumor biology, comparative genetics, functional genomics, immunology, bacteriology, and virology. The department's research is primarily fundamental, but in its application, it has a clear connection to and significance for health and disease in both animals and humans. A more detailed description can be found at Research – Department of Medical Biochemistry and Microbiology – Uppsala University

Project Description

The holder of this position will work in a research group at Uppsala University, primarily within a project that requires experience in advanced structural biology and biophysics.

Tasks

The project will involve investigating how molecules move in microRNA and how that regulates their function, and how we can ultimately manipulate it with the small molecules that will become drugs. Investigations are conducted using advanced NMR experiments and SHAPE on RNA molecules. The person will produce RNA samples using solid-phase synthesis or in vitro transcription, purify them, and then measure and determine the RNA's structure and dynamics using NMR, SHAPE, and other biophysical methods.

Qualification Requirements

Master's degree in biochemistry or biophysics. Documented laboratory experience in structural biology and biophysics, sequencing or knowledge in NMR, as well as experience in RNA handling. Requirement for very good knowledge of English, both oral and written. You must be able to work both independently and in collaboration with other group members. Great importance will be placed on personal suitability such as ability to cooperate, flexibility, precision, and a sense of responsibility.

About the Employment

Fixed-term employment for 6 months. The scope is full-time. Commencement as soon as possible or by agreement. Location: Uppsala

Information about the employment is provided by: professor Katja Petzold, e-mail: katja.petzold@imbim.uu.se or saskia.rughoft@kemi.uu.se.

Welcome with your application no later than September 18, 2026. UFV-PA 2026/2549

Uppsala University is a broad research university with a strong international position. The ultimate goal is to conduct education and research of the highest quality and relevance to make a difference in society. Our most important asset is all 7,500 employees and 53,000 students who, with curiosity and commitment, make Uppsala University one of the country's most exciting workplaces.

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