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Department of Biochemistry and Biophysics. SciLifeLab (SciLifeLab) is a national center for molecular biosciences focusing on research in health and the environment. The center combines leading technical expertise with advanced knowledge in translational medicine and molecular biosciences. SciLifelab is a national resource driven by Karolinska Institutet, KTH, Stockholms universitet and Uppsala universitet. The center collaborates with several other academic institutions.

Administratively, the employment will be placed at the Department of Biochemistry and Biophysics, Stockholms universitet. For more information about our operations, see our website: www.dbb.su.se

Project Description

A postdoctoral position is available in Emil Marklund's research lab, housed at the SciLifeLab campus Solna in Stockholm. In the Marklund lab (marklundlab.com), we investigate how the sequence of biological macromolecules governs recognition, binding, and dynamic structure. We combine high-throughput measurements of molecular binding with simulations and quantitative modeling to gain a physical understanding of life at the molecular level.

We are now recruiting a postdoc who wants to use and develop state-of-the-art methods to study the binding and dynamic structure of DNA, RNA, and proteins. Scientific questions in the project may include, for example, studying specificity in transcription factor - DNA binding, discovering protein - protein interactions, or enzyme optimization.

Tasks

The selected candidate will use and develop methods within one, or several, of the following categories:

Optical technology, fluorescence microscopy, image analysis: Development of microscopes, fluidics, and data analysis pipelines used to measure and quantify binding in high-throughput. Examples of suitable backgrounds: Optical technology, hardware-software integration, image analysis. Sequence library design, molecular cloning, and protein purification: Design and prepare molecular sequence variants for which binding is to be studied in high-throughput. Examples of suitable backgrounds: Molecular biology, protein engineering, biochemistry. Building quantitative models: Using high-throughput binding data to build sequence-dependent predictive deep learning models and physical mechanistic models (thermodynamic and kinetic models etc.). Examples of suitable backgrounds: machine learning, programming, mathematics, physics.

You will participate in designing the project according to the overall goals of the lab and you will be responsible for its implementation. We are an interdisciplinary lab and you will be encouraged to collaborate with other researchers in the team.

Eligibility Requirements

To be eligible for employment as a postdoc, a doctoral degree or a foreign degree assessed to correspond to a relevant doctoral degree is required. The degree must be awarded no later than when the employment decision is made.

Assessment Criteria

It is meritorious if the doctoral degree or equivalent was awarded at most three years before the last application date. If there are special reasons, an earlier degree may also be considered meritorious. Special reasons refer to leave due to illness, parental leave, positions of trust within trade unions, service within the total defense, or other similar circumstances as well as clinical service or service/assignments relevant to the subject area.

Upon appointment, special weight will be attached to scientific skill within the categories listed above, where special weight will be attached to skill in biophysics, molecular biology, biochemistry, optical technology, and deep machine learning.

We would also like you to have these qualities:

A curious and driven personality with a passion for fundamental research and/or method development. Good ability to work in a team. Strong publications or other evidence of scientific ability and maturity. Excellent communication skills in English. Experience in solving complex scientific problems or method development within at least one of the categories mentioned above.

About the Employment

The employment is intended to be full-time and is valid until further notice, however at least two years and at most three years, with the possibility of extension if there are special reasons. Commencement by agreement.

We Offer

With us, you get the dynamics of the interaction between higher education and research that makes Stockholms universitet an exciting and creative environment. You will work in an international environment and receive favorable conditions.

Stockholms universitet is committed to being a workplace that is free from discrimination and provides equal rights and opportunities for all.

Contact

Information about the employment is provided by Assistant Professor Emil Marklund, emil.marklund@scilifelab.se.

Application

You apply for the position via Stockholms universitet's recruitment system. Attach a personal letter and CV as well as the attachments requested in the application form. As an applicant, you are responsible for ensuring that the application is complete and that it reaches the university no later than the last application date.

Instructions for applicants can be found on the webpage: applying for a job.

Stockholms universitet contributes to the development of a sustainable democratic society through knowledge, enlightenment, and the pursuit of truth.