Scientist (m/f/d) (Protein Biomarker Assay Development and Validation)
About us
With employees from over 50 nations, CENTOGENE is a truly international company with offices is in Rostock, Berlin, Delhi, Boston, Valencia, Belgrade, and São Paulo.
We were born to help diagnostic patients with rare disease and today we evolved to help patients of all clinical specialties to make bold progress with guided solutions for physicians, their patients and pharma partners.
Your tasks
Your Responsibilities
Assay development and validation
Design, plan and execute development and validation studies for protein-based biomarker assays, e.g., ELISA and other immunoassays, proximity extension assays (PEA) and functional assays
Build robust, scalable and transferable assay workflows, and support assay transfer and the implementation of new technologies
Write high-quality validation documentation in line with internal and regulatory standards (GLP/GCLP)
Diagnostic quality and compliance
Develop and validate assays to quality standards suitable for diagnostic use, including potential in-house IVD assays in line with applicable EU regulations (e.g., IVDR)
Support clinical studies, from assay qualification to sample analysis and reporting
Handle patient samples and data responsibly and in compliance with EU data protection law (GDPR) and internal policies
Data analysis
Analyze and interpret experimental data with Excel, GraphPad Prism and R or Python, applying sound statistics to reach clear biological conclusions that guide project decisions
Use AI tools, including large language models (LLMs), responsibly for data analysis, literature research and documentation, in line with data protection and quality requirements
Where relevant, work with structured datasets and databases
Communication and collaboration
Work cross-functionally with R&D, Quality Assurance and external partners
Contribute to SOPs, reports, manuscripts and publications
Present your results internally, to partners and at scientific conferences
How you work
Your profile
Required
PhD in Biochemistry, Molecular Biology or a related field
Strong background in protein-focused biochemistry
Hands-on laboratory experience in developing and validating protein assays, e.g., immunoassays
Familiarity with working in GLP/GCLP environments
Confident data analysis with Excel and GraphPad Prism, and working experience with R and/or Python
Fluent English, written and spoken
German at A2 level or higher, and willingness to improve towards B1
A plus
Postdoctoral or industry experience
Experience with proximity extension assays and their readouts, qPCR and/or next-generation sequencing (NGS)
Knowledge of diagnostic regulations (e.g., IVDR) and data protection requirements (GDPR)
Experience with cellular models, ideally in a neurological context
Experience with, or strong interest in, the responsible use of LLMs and other AI tools in scientific work
Exposure to SQL or database environments
You plan, run and document your own studies in a structured and reliable way
You communicate results clearly, in writing and in presentations
You bring your own ideas, question existing approaches and want to help shape how the team works
Why us?
Translational research with direct relevance for patients with rare and neurodegenerative diseases
An international, multidisciplinary team and close collaboration with pharmaceutical partners
Room to take ownership of your projects, help build the team and keep learning
Support with German language courses
A 12-month contract with the possibility of transitioning to a permanent position