Research Technician (M/F)

About the company

ALPX is an EMBL spin-off located in Grenoble, providing innovative services in structural biology and small molecule discovery to pharmaceutical and biotechnology companies. Historically based on CrystalDirect technology and automated crystallography, ALPX develops and implements high-throughput experimental workflows for structural biology projects. The team operates in an international, collaborative, and scientifically stimulating environment, close to major structural biology research infrastructures and synchrotron platforms. The selected candidate will participate in various drug discovery and structural biology projects by implementing automated high-throughput X-ray crystallography workflows, with the possibility to further develop their expertise in structural biology and associated techniques.

Your tasks

• Preparation of solutions, buffers, and samples for macromolecule crystallization experiments for X-ray diffraction analysis.
• Ensure the routine use, monitoring, quality control, maintenance, and troubleshooting of automated and robotic laboratory equipment, including crystallization robots, liquid handling systems, automated imaging platforms, and crystal harvesting systems.
• Demonstrate versatility and organization to conduct multiple experiments and projects in parallel, while respecting protocols and priorities.
• Develop, apply, and update standard operating procedures (SOP) for laboratory equipment and experimental workflows.
• Ensure complete documentation of experimental procedures, results, observations, and project progress.
• Present experimental results and project progress within the scientific team.
• Provide support for laboratory activities and administrative tasks, including stock and reagent management, laboratory organization, and compliance with safety rules.
• Participate in business development and scientific communication activities, including the preparation of scientific and technical materials and supporting exchanges with clients and collaborators.

Requirements

• Bachelor's, Master's, or technician degree in biology, biotechnology, biomedical, or a related scientific field.
• At least 3 years of professional experience, ideally in a macromolecular crystallography, structural biology, or related field environment.
• Hands-on experience with laboratory robotics, automation, and high-throughput experimental workflows.
• Hands-on experience in macromolecular crystallography and protein crystallization.
• Ability to work on multiple projects and conduct several experiments in parallel.
• Excellent oral and written communication skills.
• Excellent proficiency in written and spoken English.
• Excellent organizational, documentation, and traceability skills for experimental activities.
• Ability to work effectively within a dynamic, international, and multidisciplinary team.
• Motivation to learn and implement new scientific techniques, technologies, and methodologies.