Sr Technical Product Owner

Sr Technical Product Owner (Hybrid in South San Francisco, CA)

About the Role

At Twist Bioscience, we're scaling the digital systems that power our synthetic DNA platform and enable innovation across our commercial, scientific, and operational teams. We're seeking a Senior Technical Product Owner to lead cross-functional system projects, someone who can dive deep into the details while helping improve how we work. In this role, you will own hands-on work across requirements gathering, documentation, and testing for high-impact system initiatives. We are looking for someone with a proven track record of maintaining effective business relationships to ensure IBT can deliver solutions that align with business strategies and objectives. This role sits at the intersection of product, engineering, and business. The ideal candidate has a strong analytical mindset, solid experience with enterprise and technical systems, and a knack for translating complex business and product needs into clear, executable technical requirements.

What You will do

You will serve as the primary business-facing partner on system initiatives, owning the functional definition of what needs to be built and partnering closely with engineering and project management, who own technical design, delivery sequencing, and timelines.

Requirements and Solution definition

• Lead requirements intake and clarification with business stakeholders across functions

(e.g., Product, Marketing, Sales Operations, Finance, Customer Support, and R&D).

• Define and document functional requirements, business rules, edge cases, and

acceptance criteria, including impacted existing logic, constraints, and exceptions, and translate them into epics and user stories ready for development and QA.

• Identify impacted process areas, systems, and dependencies end to end (e.g., product

setup, pricing, quoting, order intake, manufacturing, fulfillment, and invoicing), along with the SMEs and stakeholders within each.

• Drive alignment with cross-system partners and SMEs to ensure requirements are

complete and consistent across integrated systems and address emerging business needs, positioning the organization to stay ahead of new commercial requests.

• Ensure requirements and solutions are compliant and audit-ready (e.g., SOX, ISO),

partnering with Finance, Quality and other internal stakeholders.

• Demonstrate strong customer empathy and advocate for customer needs throughout the

product development process

Delivery partnership and communication

• Provide development leads, architects, and project managers with the full end-to-end

context and scope of each initiative, and lead functional grooming sessions.

• Partner with project management, scrum masters, developers, architecture, and SWQA

through design, build, testing, and delivery, clarifying requirements and surfacing risks, gaps, and dependencies early.

• Communicate proactively and consistently with business stakeholders on scope, status,

risks, and dependencies throughout each initiative.

• Influence scope tradeoffs and solution options by bringing business and cross-system

context to technical discussions.

Testing, launch, and stabilization

• Plan and lead end-to-end user acceptance testing across multiple systems: kick off with

testers, provide context and demos, support issue logging and defect clarification, and obtain stakeholder sign-off before go-live.

• Support release, hypercare, and post-launch stabilization, providing business context to

help assess the criticality of issues.

• Stay informed on production issues and contribute business and system context to their

resolution.

Continuous improvement

• Share feedback and ideas to continuously improve how the team runs projects, gathers

requirements, and tests, including intake playbooks, documentation standards, and testing practices.

• Look for opportunities to leverage AI tools to work more efficiently, such as in

requirements documentation, analysis, and testing.

Qualifications

• Bachelor's degree in a technical, engineering, or scientific field; minimum of 5+ years of

experience in a related field

• 5+ years of experience in technical product management, customer relationship

management, or products, systems, or applications experience.

• Ability to translate scientific, operational, or customer needs into functional specifications

that align with technical constraints and business goals.

• Excellent communication and collaboration skills, comfortable partnering with both

business stakeholders and technical teams.

• Growth mindset, with a drive to continuously improve systems and processes.
• Customer-centric mindset and strong sense of customer empathy
• Ability to work in a fast-paced, agile development environment

Preferred Qualifications

• Advanced degree (Master’s or PhD)
• Experience in biotech, life sciences, or synthetic biology environments.
• Hands-on experience with Salesforce (SFDC), such as Sales Cloud, Service Cloud, or

related integrations.

• Experience with Laboratory Information Management Systems (LIMS), including sample

tracking, workflow configuration, or integration with lab and enterprise systems.

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.

San Francisco Bay Area Pay Range

$160,000—$191,000 USD